The Duke University
Mathematical Biology Colloquium
- Friday, March 31, 2017, 12:00pm, 119 Physics, Mathematical Biology Seminar
Diabetes Pathogenesis as a Threshold-Crossing Process
Arthur Sherman (NIH)
- It has long been accepted that type 1 diabetes results from a lack of insulin, as the insulin-secreting pancreatic beta cells are destroyed by an autoimmune process. In contrast, the cause of type 2 diabetes (T2D) is less clear. Most people with pre-diabetes or in the early stages of T2D have abnormally high plasma insulin concentrations, and insulin rises before glucose does. We show that these difficulties are resolved by a mathematical model in which the onset of T2D is represented by the crossing of a threshold. The threshold is atypical in some respects and requires consideration of the slow manifolds to avoid incorrect conclusions.
- Friday, April 7, 2017, 12:00pm, 119 Physics, Mathematical Biology Seminar
Christine Heitsch (Georgia Institute of Technology)
- Friday, April 21, 2017, 12:00pm, 119 Physics, Mathematical Biology Seminar
Cristan Tomasetti (Johns Hopkins University)
Lunch after the talk with the speaker for interested participants.
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