The Duke University
Mathematical Biology Colloquium
- Friday, September 27, 2019, 1:30pm, Physics 227, Mathematical Biology Seminar
Mechanistic models of genetic admixture
Amy Goldberg (Duke University, Evolutionary Anthropology)
- One of the major insights from the modern genomic era is the ubiquity of migration and admixture throughout human history and the animal kingdom. Admixed populations are formed through the exchange of individuals from two or more previously isolated populations. These processes shape modern human genetic and phenotypic variation, and lead to differences in disease risk between populations. Intricate sociocultural practices such as marriage customs, colonization events, and phenotypic preferences direct how parental populations interact to form admixed human populations. Despite this complexity, previous methods often considered admixed populations as simple linear combinations of their parental populations. Instead, we describe a series of mechanistic models, considering the admixture processes such as sex-specific contributions and nonrandom mating. We demonstrate that previous work misestimates population history parameters, such as the timing and intensity of migration, and may infer admixture histories that are qualitatively different. Under a related framework, we apply the model to human population genetic data to infer human migrations and interactions through time.
- Friday, October 11, 2019, 1:30pm, Physics 227, Mathematical Biology Seminar
Inmaculada Sorribes (Duke University, Mathematics)
Lunch after the talk with the speaker for interested participants.
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