Graduate/faculty Seminar
Monday, February 8, 2016, 12:00pm, 119 Physics
Anita Layton (Duke University)
Unraveling Kidney Physiology, Pathophysiology and Therapeutics: A Modeling Approach
Abstract:- The kidney not only filters metabolic wastes and toxins from the body,
but it also regulates the body's water balance, electrolyte balance, and
acid-base balance, blood pressure, and blood flow. Despite intense
research, aspects of kidney functions remain incompletely understood. I
will discuss how our group use mathematical modeling techniques to
address a host of previously unanswered questions in renal physiology
and pathophysiology: Why is the mammalian kidney so susceptible to
hypoxia, despite receiving ~25% of the cardiac output? What are the
mechanisms underlying the development of acute kidney injury in a
patient who has undergone cardiac surgery performed on cardiopulmonary
bypass? What is the effect of inhibiting sodium-glucose transport, a
novel treatment for reducing renal glucose update in diabetes, on renal
NaCl transport and oxygen consumption? [video]
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