Mathematical Biology Seminar
Friday, March 26, 2021, 12:00pm, Virtual
Greg Forest (University of North Carolina at Chapel Hill, Mathematics, Applied Physical Sciences, Biomedical Engineering)
Modeling insights into SARS-CoV-2 respiratory tract infections
Abstract:
A large cast of UNC collaborators has been studying lung mucus biology and pathology for over 20 years, called the Virtual Lung Project. For the last 10 years with Sam Lai's group, my group has been studying how antibodies in organ mucosal barriers protect us from viral pathogens. Then along came SARS-CoV-2, not unlike previous novel viruses and human vulnerability. We have the advantage of "intel" from colleagues in the UNC Marsico Lung Institute and their relationships and practices. We leverage their scientific, physiological, and clinical knowledge with our mechanistic modeling to explore clinical outcomes of SARS-CoV-2 prior to an immune response. This modeling platform is poised to integrate immune responses and medical interventions, but that is for the future. I'll acknowledge the band we put back together again to adapt our previous capabilities, and focus on explanations of clinical outcomes, how they do and do not happen, and critical open questions raised by our results.

Email ciocanel@math.duke.edu to request the Zoom link and password for the talk (or subscribe to announcements at https://lists.duke.edu/sympa/info/mathbio-seminar).

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