Mathematical Biology Seminar
Friday, January 24, 2020, 1:30pm, 119 Physics
Kris Wood
Targeting the drug resistant state in cancer
Abstract:- In most cases, our best available therapies fail to durably
eradicate advanced malignancies. Instead, over time, cancers re-emerge
with acquired resistance to the agents used against them. In the past
decade, work from our lab and others has demonstrated that resistance to a
given agent can be driven by diverse molecular mechanisms, and that these
mechanisms typically co-occur within individual patients. As a
consequence, strategies to target individual resistance mechanisms are
typically ineffective, while strategies to simultaneously target many
diverse resistance mechanisms are too toxic to be administered to
patients. This challenge has motivated work in our group to define new
conceptual strategies to target resistance in cancer. In this talk, I will
outline one such strategy, which involves the identification,
characterization, and therapeutic targeting of ³collateral sensitivities²
- therapeutic vulnerabilities that arise as a consequence of resistance
evolution and which, in some cases, are shared across tumor cell clones
driven by diverse resistance mechanisms. Our long term goal is to use
these principles to define therapeutic strategies that have the unique
ability to select against resistance evolution, and I will end my talk
with empirical evidence of this concept.
Generated at 2:43pm Friday, April 19, 2024 by Mcal. Top
* Reload
* Login