Probability Seminar
Thursday, February 1, 2018, 3:15pm, 119 Physics
Paul Bressloff (University of Utah, Mathematics)
Stochastic models of intracellular transport: a PDE perspective
Abstract:
The efficient delivery of proteins and other molecular products to their correct location within a cell (intracellular transport) is of fundamental importance to normal cellular function and development. Moreover, the breakdown of intracellular transport is a major contributing factor to many degenerative diseases. There are two major types of transport. (I) Passive diffusion within the cytosol or the surrounding plasma membrane of the cell. Since the aqueous environment (cytosol) of a cell is highly viscous at the length and velocity scales of macromolecules (low Reynolds number), a diffusing particle can be treated as an overdamped Brownian particle where inertial effects are ignored. (II) Active motor-driven transport along polymerized filaments such as microtubules and F-actin that comprise the cytoskeleton. At appropriate length and time scales, active transport can either be modeled as a velocity-jump process or as an advection-diffusion process. In this talk I present various PDE models of active and passive transport within cells. The bulk of the talk will focus on three examples: synaptic democracy and vesicular transport in axons and dendrites; stochastically gated diffusion in bounded domains; cytoneme-based transport of morphogens during embryogenesis. (A cytoneme is a thin actin-rich filament that forms direct contacts between cells and is thought to provide an alternative to diffusion-based morphogen gradient formation.) Other applications include cellular length control, cell polarization, and synaptogenesis in C. elegans. [video]

Generated at 1:15pm Thursday, March 28, 2024 by Mcal.   Top * Reload * Login