Estimating birth and death of immune cell populations using cell cycle based models.

We use age structured cell cycle models to estimate birth/death rates in a population of immune cells from the kinetics of age distribution of cells in the population. Our model generalizes the approach of Smith and Martin in using a two stage cell cycle model to interprete the FLM curves. We developed this model to quantify the CFSE dye dilution assays for a marked population of immune cells.